Research

Identified key epigenetic mechanisms of iPSC reprogramming through integrative multi-omics 

Developed snm3C, a single-cell multi-modal omics method linking DNA methylation and 3D genome; featured in BRAIN Initiative.

Published Hi-C/CRISPR study showing that structural variants induce novel chromatin interactions, and that epigenomic changes are essential for oncogene activation. 

snm3C reveals spatially enriched chromatin interactions and sequential epigenomic remodeling during human brain development

This project aims to comprehensively map and functionally analyze the epigenome in cancers, including gastric, liver, colorectal, and kidney cancers, using normal–tumor pairs. Leveraging single-cell multi-omics technologies, we simultaneously profile spatial information, DNA methylation, 3D genome architecture, transcriptome, and structural variations. We identify regulatory targets by analyzing multiple enhancers within TADs and develop multiplexed CRISPR-based tools to modulate TAD activity.

This project aims to develop a next-generation forensic analysis platform that enables the identification of individual contributors from mixed DNA samples collected at crime scenes.